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KMID : 1161420230260020104
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Journal of Medicinal Food
2023 Volume.26 No. 2 p.104 ~ p.113
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Dietary Soy Isoflavones Prevent Metabolic Disturbs Associated with a Deleterious Combination of Obesity and Menopause
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Luciano Evangelista dos Santos Filho
Grazielle Prates Lourenco dos Santos
Jussara Andrade Silva
Fernanda de Abreu Silva
Mirlana Neves Silva
Amanda Alves de Almeida
Raildo da Silva Coqueiro
Candido Celso Coimbra
Telma de Jesus Soares
Amelia Cristina Mendes de Magalhaes
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Abstract
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This study aimed to evaluate the effects of soy isoflavone supplementation (25?mg/kg) on insulin resistance and inflammation in adipose tissue in an experimental model of menopause?obesity. Twenty-four female Wistar rats were ovariectomized (O) and distributed among the groups: OSD?ovariectomized rats submitted to normocaloric standard diet (n?=?6); OHF?ovariectomized rats submitted to high-fat diet (n?=?9); and OHFI?ovariectomized rats submitted to high-fat diet with isoflavones (n?=?9). Weight gain, body adiposity, food and caloric intake, blood pressure, and glucose tolerance were assessed. After 24 weeks, the rats were euthanized; the thoracic blood collected for serum insulin determination and the homeostatic model assessment-insulin resistance) (HOMA-IR) and homeostatic model assessment-β cell (HOMA-β) indices were calculated. Abdominal adipose tissues were removed, weighed, and fixed for immunohistochemical and morphometric studies. Isoflavones decreased weight gain and blood pressure without changing the food and caloric intake (P?
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KEYWORD
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adipose tissue, diet, inflammation, insulin, metabolism, phytoestrogens
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